Tapping into the diversity of life to inform mechanisms underlying shared traits.

Through targeted capture approaches including over 250,000 unique baits covering both coding and conserved non coding elements, we systematically have isolated and annotated genome wide sequence complement and variation across over 250 different species of fishes. Through analysis of particular clades having fixed unique, defining, characters, we use our phylomapping approach to identify genetic signatures associating with the trait during evolution. We subsequently model these changes in zebrafish, mouse, or compare directly with variation in long-lived human populations.

Related Projects

Key Publications

  • Treaster S, Deleen J, Daane J, Murabito J, Karasik D, Harris MP (2021) Genomics of exceptional longevity in rockfishes refine genetic foundations of human lifespan variation
  • Daane, JM, Lanni J, Blum N, Iovine MK, Higdon CS, Johnson SL, Lovejoy NR, Harris MP (2021) Modulation of bioelectric cues in the evolution of flying fishes. Current Biology. Sep 13;S0960-9822(21)01190-8. doi: 10.1016/j.cub.2021.08.054
  • Daane JM, Dauberg A, Hawkins MB, Smits, P., Warman M, Near T, Detrich W, Harris MP. (2019). Phylogenomic evidence of genetic changes that presage radiation of Antarctic notothenioids. Nature Eco Evol. Jul;3(7):1102-1109. PMID: 31182814
  • Daane JM, Rohner N, Konstantinidis P, Djuranovic S, and Harris MP. (2016) Phylogenomic evidence for parallelism and correlative selection during fish skeletal evolution. Molecular Biology and Evolution, Jan;33(1):162-73. PMID: 26452532

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